Cat. No.

CBCRY05

Background

The SARS-CoV main protease, which is a 33.8-kDa protease (also called the 3C-like protease), plays a pivotal role in mediating viral replication and transcription functions through extensive proteolytic processing of two replicase polyproteins, pp1a (486 kDa) and pp1ab (790 kDa).

Molecular description

Protein Classification

Hydrolase

Structure Weight

69623.62

Polymer

1

Molecule

3C-like proteinase

Chain Length

306 amino acids

Polymer

2

Molecule

5-mer peptide of inhibitor 

Chain Length

5 amino acids

Crystal Description

PDB ID

1UK4

MMDB ID

25518

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.5 Å

Ligand Chemical Component

Chloroacetone

Gene information

Gene Name

NEWENTRY

Synonyms

3C-like proteinase

GeneID

2831005

Function

RNA binding; catalytic activity; RNA-directed RNA polymerase activity; peptidase activity; cysteine-type peptidase activity; zine ion binding; hydrolase activity; metal ion binding

Reference

Yang H, Yang M, Ding Y, Liu Y, Lou Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, Gao GF, Anand K, Bartlam M, Hilgenfeld R, Rao Z. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13190-13195.