Cat. No.

CBCRY06

Background

Human FcalphaRI (CD89) is the receptor specific for IgA, an immunoglobulin that is abundant in mucosa and is also found in high concentrations in serum. Although FcalphaRI is an immunoglobulin Fc receptor (FcR), it differs in many ways from FcRs for other immunoglobulin classes. The genes of most FcRs are located on chromosome 1 at 1q21-23, whereas FcalphaRI is on chromosome 19, at 19q13.4, a region called the leukocyte receptor complex, because it is clustered with several leukocyte receptor families including killer cell inhibitory receptors (KIRs) and leukocyte Ig-like receptors (LIRs). The amino acid sequence of FcalphaRI shares only 20% homology with other FcRs but it has around 35% homology with its neighboring LIRs and KIRs.

Molecular description

Protein Classification

Immune System

Structure Weight

25006.40 Da

Polymer

1

Molecule

Immunoglobulin alpha Fc receptor

Chain Length

218 amino acids

Crystal Description

PDB ID

1UCT

MMDB ID

24338

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.1 Å

Gene information

Gene Name

FCAR

Synonyms

XXbac-BPG230H20.5, CD89; Fc alpha receptor; IgA Fc receptor; OTTHUMP00000068692; OTTHUMP00000068696; OTTHUMP00000068697; OTTHUMP00000068698; CD89; CD89 antigen; Fc receptor; Fc fragment of IgA, receptor; IgA Fc receptor

UniProt ID

P24071

GeneID

2204

Chromosome  Location

19q13.2-q13.4

Function

IgA binding; receptor activity

Reference

Ding, Y.,  Xu, G.,  Yang, M.,  Yao, M.,  Gao, G.F.,  Zhang, W.,  Rao, Z. Crystal Structure of the Ectodomain of Human Fc{alpha}RI.J.Biol.Chem. 2003; 278: 27966-27970