Cat. No.

CBCRY10

Background

IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity.

Molecular description

Protein Classification

Isomerase

Structure Weight

56107.39 Da

Polymer

1

Molecule

Isopentenyl-diphosphate delta-isomerase 1

Chain Length

255 amino acids

Crystal Description

PDB ID

2I6K

MMDB ID

46256

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.00 Å

Ligand Chemical Component

Acetic acid; Aminoethanolpyrophosphate; Magnesium ion; Manganese ion

Gene information

Gene Name

IDI1

Synonyms

IPP1; IPPI1; EC 5.5.5.2; IPP isomerase; IPP isomerase; OTTHUMP00000018951; isopentenyl diphosphate dimethylallyl diphosphate isomerase 1; isopentenyl pyrophosphate isomerase 1; isopentenyl-diphosphate delta isomerase

UniProt ID

Q13907

GeneID

3422

Chromosome  Location

10p15.3

Function

magnesium ion binding; isopentenyl-diphosphate delta-isomerase activity; hydrolase activity; isomerase activity; metal ion binding

Reference

Zhang, C.,  Liu, L.,  Xu, H.,  Wei, Z.,  Wang, Y.,  Lin, Y.,  Gong, W. (2007) Crystal structures of human IPP isomerase: new insights into the catalytic mechanism J.Mol.Biol. 366: 1437-1446