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Cat. No.
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CBCRY18
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Background
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Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor: the p75 neurotrophin receptor (p75(NTR)) and tyrosine kinase receptors (Trks). Whereas p75(NTR) binds to all NTs, the Trk subtypes are specific for each NT.
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Molecular description
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Protein Classification
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signaling protein
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Structure Weight
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63861.22
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Polymer
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1
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Molecule
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Neurotrophin-3
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Chain Length
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119 amino acids
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Polymer
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2
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Molecule
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Tumor necrosis factor receptor superfamily member 16
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Chain Length
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167 amino acids
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Crystal Description
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PDB ID
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3BUK
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MMDB ID
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65479
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Source
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E.coli
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Method
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X-Ray Diffraction
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Resolution
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2.6Å
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Ligand Chemical Component
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N-Acetyl-D-Glucosamine
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Gene information
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Gene Name
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NTF3
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Synonyms
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HDNF; MGC129711; NGF-2; NGF2; NT3; Nerve growth factor 2; neurotrophic factor; neurotrophin 3
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UniProt ID
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P20783
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GeneID
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4908
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Chromosome Location
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12p13
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Function
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growth factor activity; nerve growth factor binding; neurotrophin receptor binding
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Gene Name
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NGFR
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Synonyms
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CD271; Gp80-LNGFR; TNFRSF16; p75(NTR); p75NTR; low affinity nerve growth factor receptor; low-affinity nerve growth factor receptor; nerve growth factor receptor; CD271 antigen; NGF receptor; nerve growth factor receptor
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UniProt ID
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P08138
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GeneID
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4804
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Chromosome Location
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17q21-q22
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Function
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death receptor activity; nerve growth factor binding; protein binding
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Reference
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Gong, Y., Cao, P., Yu, H.J., Jiang, T. (2008) Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature 454: 789-793
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