Cat. No.

CBCRY28

Background

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.

Molecular description

Protein Classification

Signaling Protein

Structure Weight

15255.28 Da

Polymer

1

Molecule

Rho guanine nucleotide exchange factor 7

Chain Length

61 amino acids

Crystal Description

PDB ID

2ESW

MMDB ID

38672

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.01Å

Ligand Chemical Component

Chloride ion; Mercury ion

Gene information

Gene Name

Arhgef7

Synonyms

PIX; Cool; Pak3bp; cool-1; p85SPR; betaPix; p85Cool1; betaPix-b; betaPix-c; mKIAA0142; Arhgef7; PAK-interacting exchange factor beta; OTTMUSP00000023238; Pak3 binding protein; Pak interacting exchange factor; Dkfzp761k1021; kiaa0412; p50; p50bp; p85; pak3; pixb  

UniProt ID

Q6XPA5

GeneID

54126

Chromosome  Location

8 A1.1

Function

guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; protein binding

Reference

Li, X.,  Liu, X.,  Sun, F.,  Gao, J.,  Zhou, H.,  Gao, G.F.,  Bartlam, M.,  Rao, Z. (2006) Crystal structure of the N-terminal SH3 domain of mouse betaPIX, p21-activated kinase-interacting exchange factor Biochem. Biophys. Res. Commun.  339: 407-414