Cat. No.

CBCRY36

Background

3'-Azido-3'-deoxythymidine (AZT) is the first clinically effective drug for the treatment of human immunodeficiency virus infection. The drug interaction with human serum albumin (HSA) has been an important component in understanding its mechanism of action, especially in drug distribution and in drug-drug interaction on HSA in the case of multi-drug therapy.

Molecular description

Protein Classification

Lipid binding protein

Structure Weight

68485.53 Da

Polymer

1

Molecule

Serum albumin

Chain Length

585 amino acids

Crystal Description

PDB ID

3B9M

MMDB ID

64671

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.70Å

Ligand Chemical Component

AZZ; Myristic acid; 2-hydroxybenzoic acid

Gene information

Gene Name

ALB

Synonyms

DKFZp779N1935; PRO0883; PRO0903; PRO1341; cell growth inhibiting protein 42; growth-inhibiting protein 20; serum albumin

UniProt ID

P02768

GeneID

213

Chromosome  Location

4q11-q13

Function

DNA binding; fatty acid binding; copper ion binding; protein binding; drug binding; lipid binding; toxin binding; antioxidant activity; oxygen binding; pyridoxal phosphate binding; metal ion binding

Reference

Zhu, L.,  Yang, F.,  Chen, L.,  Meehan, E.J.,  Huang, M. (2008) A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography J.Struct.Biol. 162: 40-49