Cat. No.

CBCRY37

Background

Poly(A) binding protein, nuclear 1, also known as PABPN1, is required for progressive and efficient polymerization of poly(A) tails on the 3' ends of eukaryotic genes and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm.

Molecular description

Protein Classification

RNA binding protein

Structure Weight

43445.20 Da

Polymer

1

Molecule

Polyadenylate-binding protein 2

Chain Length

96 amino acids

Crystal Description

PDB ID

3B4M

MMDB ID

61872  

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.82Å

Gene information

Gene Name

PABPN1

Synonyms

OPMD; PAB2; PABP2; poly(A) binding protein 2; poly(A) binding protein II; poly(A) binding protein, nuclear 1

UniProt ID

Q86U42

GeneID

8106

Chromosome  Location

14q11.2-q13

Function

nucleotide binding; nucleic acid binding; RNA binding; protein binding

Reference

Ge, H.,  Zhou, D.,  Tong, S.,  Gao, Y.,  Teng, M.,  Niu, L. (2008) Crystal structure and possible dimerization of the single RRM of human PABPN1 Proteins 71: 1539-1545