Cat. No.

CBCRY38

Background

VPS29 belongs to a group of genes coding for vacuolar protein sorting (VPS) proteins that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene, Vps29, is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. Vps29 may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment.

Molecular description

Protein Classification

cytoplasmic protein

Structure Weight

20531.90 Da

Polymer

1

Molecule

Vacuolar Protein Sorting Protein 29

Chain Length

182 amino acids

Crystal Description

PDB ID

1W24

MMDB ID

32322

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.10Å

Gene information

Gene Name

VPS29

Synonyms

DC15; DC7; DKFZp564F0223; FLJ20492; PEP11; retromer protein; vacuolar protein sorting 29; vacuolar sorting protein VPS29/PEP11; x 007 protein; EC 3.1.3.3; hVPS29; vesicle protein sorting 29

UniProt ID

Q9UBQ0

GeneID

51699

Chromosome  Location

12q24

Function

zinc ion binding; hydrolase activity; metal ion binding

Reference

Wang, D.,  Guo, M.,  Liang, Z.,  Fan, J.,  Zhu, Z.,  Zang, J.,  Zhu, Z.,  Li, X.,  Teng, M.,  Niu, L.,  Dong, Y.,  Liu, P. (2005) Crystal Structure of Human Vacuolar Protein Sorting Protein 29 Reveals a Phosphodiesterase/Nuclease-Like Fold and Two Protein-Protein Interaction Sites. J.Biol.Chem. 280: 22962