Cat. No.

CBCRY39

Background

Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Molecular description

Protein Classification

hydrolase

Structure Weight

114694.18 Da

Polymer

1

Molecule

Caspase-3

Chain Length

253 amino acids

Crystal Description

PDB ID

3DEK

MMDB ID

66481

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.4Å

Ligand Chemical Component

Cysteinesulfonic acid

Gene information

Gene Name

CASP3

Synonyms

CPP32; CPP32B; procaspase3; Yama; SCA-1; OTTHUMP00000165054; PARP cleavage protease; SREBP cleavage activity 1; apopain; caspase 3; caspase 3, apoptosis-related cysteine protease; cysteine protease CPP32;  

UniProt ID

P42574

GeneID

836

Chromosome  Location

4q34

Function

cysteine-type endopeptidase activity; cyclin-depedent protein kinase inhibitor activity; peptidase activity; cysteine-type peptidase activity; hydrolase activity

Reference

Du, J.-Q.,  Wu, J.,  Zhang, H.-J.,  Zhang, Y.-H.,  Qiu, B.-Y.,  Wu, F.,  Chen, Y.-H.,  Li, J.-Y.,  Nan, F.-J.,  Ding, J.-P.,  Li, J. (2008) Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem. 283: 30205-30215