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3CLpro Protein Crystal

(CBCRY05)  Download Datasheet
Background
Background
The SARS-CoV main protease, which is a 33.8-kDa protease (also called the 3C-like protease), plays a pivotal role in mediating viral replication and transcription functions through extensive proteolytic processing of two replicase polyproteins, pp1a (486 kDa) and pp1ab (790 kDa).
Molecular Description
Protein Classification
Hydrolase
Structure Weight
69623.62 Da
Polymer
1
Molecule
3C-like proteinase
Chain Length
306 amino acids
Polymer
2
Molecule
5-mer peptide of inhibitor
Chain Length
5 amino acids
Crystal Description
PDB ID
1UK4
MMDB ID
25518
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.5 Å
Ligand Chemical Component
Chloroacetone
Gene Information
Gene Name
NEWENTRY
Synonyms
3C-like proteinase
Gene ID
2831005
Function
RNA binding; catalytic activity; RNA-directed RNA polymerase activity; peptidase activity; cysteine-type peptidase activity; zine ion binding; hydrolase activity; metal ion binding
Gene Name
NEWENTRY
Synonyms
3C-like proteinase
Gene ID
2831005
Function
RNA binding; catalytic activity; RNA-directed RNA polymerase activity; peptidase activity; cysteine-type peptidase activity; zine ion binding; hydrolase activity; metal ion binding
Reference
Reference
Yang H, Yang M, Ding Y, Liu Y, Lou Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, Gao GF, Anand K, Bartlam M, Hilgenfeld R, Rao Z. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13190-13195.