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AKT2 Protein Crystal

(CBCRY43)  Download Datasheet
Background
Background
AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Overexpression of this gene contributes to the malignant phenotype of a subset of human ductal pancreatic cancers.
Molecular Description
Protein Classification
Kinase
Structure Weight
38884.90 Da
Polymer
1
Molecule
RAC-BETA SERINE/THREONINE PROTEIN KINASE
Chain Length
335 amino acids
Crystal Description
PDB ID
1GZN
MMDB ID
22886
Source
Insect cells
Method
X-Ray Diffraction
Resolution
2.50 Å
Gene Information
Gene Name
AKT2
Synonyms
PKBB; PRKBB; HIHGHH; PKBBETA; RAC-BETA
UniProt ID
P31751
Gene ID
208
Chromosome Location
19q13.1-q13.2
Function
ATP binding; kinase activity; protein serine/threonine kinase activity
Reference
Reference
Yang J, Cron P, Thompson V, Good V, Hess D, Hemmings BA, Barford D. Molecular mechanism for the regulation of protein kinase b/akt by hydrophobic motif phosphorylation. Mol.Cell (2002) 9 p.1227