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ALB Protein Crystal

(CBCRY36)  Download Datasheet
Background
Background
3'-Azido-3'-deoxythymidine (AZT) is the first clinically effective drug for the treatment of human immunodeficiency virus infection. The drug interaction with human serum albumin (HSA) has been an important component in understanding its mechanism of action, especially in drug distribution and in drug-drug interaction on HSA in the case of multi-drug therapy.
Molecular Description
Protein Classification
Lipid binding protein
Structure Weight
68485.53 Da
Polymer
1
Molecule
Serum albumin
Chain Length
585 amino acids
Crystal Description
PDB ID
3B9M
MMDB ID
64671
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.70Å
Ligand Chemical Component
AZZ; Myristic acid; 2-hydroxybenzoic acid
Gene Information
Gene Name
ALB
Synonyms
DKFZp779N1935; PRO0883; PRO0903; PRO1341; cell growth inhibiting protein 42; growth-inhibiting protein 20; serum albumin
UniProt ID
P02768
Gene ID
213
Chromosome Location
4q11-q13
Function
DNA binding; fatty acid binding; copper ion binding; protein binding; drug binding; lipid binding; toxin binding; antioxidant activity; oxygen binding; pyridoxal phosphate binding; metal ion binding
Reference
Reference
Zhu, L., Yang, F., Chen, L., Meehan, E.J., Huang, M. (2008) A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography J.Struct.Biol. 162: 40-49