Creative Biostructure

Online Inquiry

Please enter "biostructure" as the verification code.

ARHGEF7 Protein Crystal

(CBCRY28)  Download Datasheet
Background
Background
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.
Molecular Description
Protein Classification
Signaling Protein
Structure Weight
15255.28 Da
Polymer
1
Molecule
Rho guanine nucleotide exchange factor 7
Chain Length
61 amino acids
Crystal Description
PDB ID
2ESW
MMDB ID
38672
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.01Å
Ligand Chemical Component
Chloride ion; Mercury ion
Gene Information
Gene Name
Arhgef7
Synonyms
PIX; Cool; Pak3bp; cool-1; p85SPR; betaPix; p85Cool1; betaPix-b; betaPix-c; mKIAA0142; Arhgef7; PAK-interacting exchange factor beta; OTTMUSP00000023238; Pak3 binding protein; Pak interacting exchange factor; Dkfzp761k1021; kiaa0412; p50; p50bp; p85; pak3; pixb
UniProt ID
Q6XPA5
Gene ID
54126
Chromosome Location
8 A1.1
Function
guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; protein binding
Reference
Reference
Li, X., Liu, X., Sun, F., Gao, J., Zhou, H., Gao, G.F., Bartlam, M., Rao, Z. (2006) Crystal structure of the N-terminal SH3 domain of mouse betaPIX, p21-activated kinase-interacting exchange factor Biochem. Biophys. Res. Commun. 339: 407-414