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ARTN Protein Crystal

(CBCRY32)  Download Datasheet
Background
Background
Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET.
Molecular Description
Protein Classification
Hormone/growth Factor
Structure Weight
11574.40 Da
Polymer
1
Molecule
neurotrophic factor artemin isoform 3
Chain Length
105 amino acids
Crystal Description
PDB ID
2GYZ
MMDB ID
40051
Source
E.coli
Method
X-Ray Diffraction
Resolution
1.76Å
Gene Information
Gene Name
ARTN
Synonyms
ENOVIN; EVN; NBN; OTTHUMP00000009173; OTTHUMP00000009174; neublastin; neurotrophic factor; neurotrophic factor artemin
UniProt ID
Q5T4W7
Gene ID
9048
Chromosome Location
1p33-p32
Function
growth factor activity; receptor binding
Reference
Reference
Wang, X., Baloh, R.H., Milbrandt, J., Garcia, K.C. (2006) Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure 14: 1083-1092