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BPGM Protein Crystal

(CBCRY13)  Download Datasheet
Background
Background
Bisphosphoglycerate mutase is an erythrocyte-specific enzyme catalyzing a series of intermolecular phosphoryl group transfer reactions. Its main function is to synthesize 2,3-bisphosphoglycerate, the allosteric effector of hemoglobin.
Molecular Description
Protein Classification
Isomerase
Structure Weight
63399.57 Da
Polymer
1
Molecule
Bisphosphoglycerate mutase
Chain Length
271 amino acids
Crystal Description
PDB ID
2HHJ
MMDB ID
53343
Source
E.coli
Method
X-Ray Diffraction
Resolution
1.5 Å
Ligand Chemical Component
3-phosphoglyceric acid; 2,3-diphosphoglyceric acid; cyclohexylammonium ion
Gene Information
Gene Name
BPGM
Synonyms
EC 5.4.2.4; EC 5.4.2.1; EC 3.1.3.13; 2,3-bisphosphoglycerate mutase; 2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase; BPG-dependent PGAM
UniProt ID
P07738
Gene ID
669
Chromosome Location
7q31-q34
Function
bisphosphoglycerate 2-phosphatase activity; bisphosphoglycerate mutase activity; hydrolase activity; isomerase activity; phosphoglycerate mutase activity; intramolecular transferase activity; phosphatrasferase
Reference
Reference
Wang, Y., Liu, L., Wei, Z., Cheng, Z., Lin, Y., Gong, W. (2006) Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase. J.Biol.Chem. 281: 39642-39648