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CASP3 Protein Crystal(CBCRY39)

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Product Summary
Name CASP3 Protein Crystal
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Cat No.CBCRY39
FragmentFull length
Protein DescriptionCaspase-3
BackgroundCaspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Protein Classificationhydrolase
Structure Weight114694.18 Da
MethodX-Ray Diffraction
Resolution2.4Å
Ligand Chemical ComponentCysteinesulfonic acid
ReferenceDu, J.-Q., Wu, J., Zhang, H.-J., Zhang, Y.-H., Qiu, B.-Y., Wu, F., Chen, Y.-H., Li, J.-Y., Nan, F.-J., Ding, J.-P., Li, J. (2008) Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem. 283: 30205-30215

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