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CASP3 Protein Crystal

(CBCRY39)  Download Datasheet
Background
Background
Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Molecular Description
Protein Classification
hydrolase
Structure Weight
114694.18 Da
Polymer
1
Molecule
Caspase-3
Chain Length
253 amino acids
Crystal Description
PDB ID
3DEK
MMDB ID
66481
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.4Å
Ligand Chemical Component
Cysteinesulfonic acid
Gene Information
Gene Name
CASP3
Synonyms
CPP32; CPP32B; procaspase3; Yama; SCA-1; OTTHUMP00000165054; PARP cleavage protease; SREBP cleavage activity 1; apopain; caspase 3; caspase 3, apoptosis-related cysteine protease; cysteine protease CPP32;
UniProt ID
P42574
Gene ID
836
Chromosome Location
4q34
Function
cysteine-type endopeptidase activity; cyclin-depedent protein kinase inhibitor activity; peptidase activity; cysteine-type peptidase activity; hydrolase activity
Reference
Reference
Du, J.-Q., Wu, J., Zhang, H.-J., Zhang, Y.-H., Qiu, B.-Y., Wu, F., Chen, Y.-H., Li, J.-Y., Nan, F.-J., Ding, J.-P., Li, J. (2008) Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem. 283: 30205-30215