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CLIC4 Protein Crystal

(CBCRY20)  Download Datasheet
Background
Background
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).
Molecular Description
Protein Classification
Transport protein
Structure Weight
89641.50 Da
Polymer
1
Molecule
Chloride intracellular channel protein 4
Chain Length
261 amino acids
Crystal Description
PDB ID
2D2Z
MMDB ID
39169
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.8Å
Gene Information
Gene Name
CLIC4
Synonyms
CLIC4L; DKFZp566G223; FLJ38640; H1; MTCLIC; huH1; p64H1; OTTHUMP00000003380; chloride intracellular channel 4 like; Intracellular chloride ion channel protein p64H1
UniProt ID
Q9Y696
Gene ID
25932
Chromosome Location
1p36.11
Function
chloride ion binding; protein binding; voltage-gated chloride channel activity; voltage-gated ion channel activity.
Reference
Reference
Li, Y.F., Li, D.F., Zeng, Z.H., Wang, D.C. (2006) Trimeric structure of the wild soluble chloride intracellular ion channel CLIC4 observed in crystals Biochem.Biophys.Res.Commun. 343: 1272-1278