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CRYM Protein Crystal

(CBCRY14)  Download Datasheet
Background
Background
Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Multiple alternatively spliced transcript variants have been found for this gene.
Molecular Description
Protein Classification
Oxidoreductase
Structure Weight
68589.65 Da
Polymer
1
Molecule
Mu-crystallin homolog
Chain Length
312 amino acids
Crystal Description
PDB ID
2I99
MMDB ID
44495
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.6 Å
Ligand Chemical Component
NAD
Gene Information
Gene Name
CRYM
Synonyms
DFNA40; THBP; NADP-regulated thyroid-hormone binding protein; OTTHUMP00000115878; dfna40; crystallin mu
UniProt ID
Q14894
Gene ID
1428
Chromosome Location
16p13.11-p12.3
Function
NADP or NADPH binding; catalytic activity; thyroid hormone binding; transcription corepressor activity
Reference
Reference
Cheng, Z., Sun, L., He, J., Gong, W. (2007) Crystal structure of human {micro}-crystallin complexed with NADPH Protein Sci. 16: 329-335