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DAAO Protein Crystal

(CBCRY46)  Download Datasheet
Background
Background
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The D-amino acid oxidase is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. It regulates the level of the neuromodulator D-serine in the brain, has high activity towards D-DOPA and contributes to dopamine synthesis.
Molecular Description
Protein Classification
Oxidoreductase
Structure Weight
161715.92 Da
Polymer
1
Molecule
D-amino-acid oxidase
Chain Length
347 amino acids
Crystal Description
PDB ID
2DU8
MMDB ID
42655
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.50 Å
Ligand Chemical Component
BEZ, FAD
Gene Information
Gene Name
DAO
Synonyms
DAAO; OXDA; DAMOX
UniProt ID
P14920
Gene ID
1610
Chromosome Location
12q24
Function
cofactor binding; D-amino-acid oxidase activity; FAD binding; protein dimerization activity; receptor binding
Reference
Reference
Kawazoe T, Tsuge H, Pilone MS, Fukui K. Crystal structure of human d-amino acid oxidase: context-dependent variability of the backbone conformation of the vaagl hydrophobic stretch located at the si-face of the flavin ring. Protein Sci. (2006) 15 p.2708