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DNCL2A Protein Crystal

(CBCRY31)  Download Datasheet
Background
Background
The human light chain of the motor protein dynein, Dnlc2A, is also a novel TGF-beta-signaling component, which is altered with high frequency in epithelial ovarian cancer. It is an important mediator of dynein and the development of cancer, owing to its ability to bind to the dynein intermediate light chain (DIC) IC74 and to regulate TGF-beta-dependent transcriptional events.
Molecular Description
Protein Classification
Transport Protein
Structure Weight
24324.71 Da
Polymer
1
Molecule
Dynein light chain 2A, cytoplasmic
Chain Length
106 amino acids
Crystal Description
PDB ID
2HZ5
MMDB ID
53434
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.10Å
Ligand Chemical Component
Cesium ion
Gene Information
Gene Name
DYNLRB1
Synonyms
BITH; BLP; DNCL2A; DNLC2A; ROBLD1; OTTHUMP00000030691; ROBL/LC7-like 1; Roadblock-1; bithoraxoid-like protein; cytoplasmic dynein light chain 2A; dynein, cytoplasmic, light polypeptide 2A; dynein-associated protein HKM23; dynein-associated protein Km23; roadblock domain containing 1
UniProt ID
Q9NP97
Gene ID
83658
Chromosome Location
20q11.21
Function
microtubule motor activity; protein binding
Reference
Reference
Liu, J.-F., Wang, Z.-X., Wang, X.-Q., Tang, Q., An, X.-M., Gui, L.-L., Liang, D.-C. (2006) Crystal structure of human dynein light chain Dnlc2A: Structural insights into the interaction with IC74 Biochem.Biophys.Res.Commun. 349: 1125-1129