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EIF3K Protein Crystal

(CBCRY12)  Download Datasheet
Background
Background
eIF3k, the smallest subunit of eukaryotic initiation factor 3 (eIF3), interacts with several other subunits of eIF3 and the 40 S ribosomal subunit. eIF3k is conserved among high eukaryotes, including mammals, insects, and plants, and it is ubiquitously expressed in human tissues. Interestingly, eIF3k does not exist in some species of yeast. Thus, eIF3k may play a unique regulatory role in higher organisms.
Molecular Description
Protein Classification
Biosynthetic protein
Structure Weight
26532.46 Da
Polymer
1
Molecule
Eukaryotic translation initiation factor 3 subunit 11
Chain Length
250 amino acids
Crystal Description
PDB ID
1RZ4
MMDB ID
29334
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.1 Å
Ligand Chemical Component
sulfate ion
Gene Information
Gene Name
EIF3K
Synonyms
ARG134; EIF3-p28; EIF3S12; HSPC029; M9, MSTP001; PLAC-24,;PLAC24; PRO1474; PTD001; Eukaryotic translation initiation factor 3 subunit 12; Muscle-specific gene M9 protein; eIF-3 p25; eIF-3 p28; eukaryotic translation initiation factor 3, subunit K; muscle specific; ptd001
UniProt ID
Q9UBQ5
Gene ID
27335
Chromosome Location
19q13.2
Function
translation initiator factor activity; protein binding; ribosome binding
Reference
Reference
Wei, Z., Zhang, P., Zhou, Z., Cheng, Z., Wan, M., Gong, W. (2004) Crystal structure of human eIF3k, the first structure of eIF3 subunits J.Biol.Chem. 279: 34983-34990