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FCAR Protein Crystal

(CBCRY06)  Download Datasheet
Background
Background
Human FcalphaRI (CD89) is the receptor specific for IgA, an immunoglobulin that is abundant in mucosa and is also found in high concentrations in serum. Although FcalphaRI is an immunoglobulin Fc receptor (FcR), it differs in many ways from FcRs for other immunoglobulin classes. The genes of most FcRs are located on chromosome 1 at 1q21-23, whereas FcalphaRI is on chromosome 19, at 19q13.4, a region called the leukocyte receptor complex, because it is clustered with several leukocyte receptor families including killer cell inhibitory receptors (KIRs) and leukocyte Ig-like receptors (LIRs). The amino acid sequence of FcalphaRI shares only 20% homology with other FcRs but it has around 35% homology with its neighboring LIRs and KIRs.
Molecular Description
Protein Classification
Immune System
Structure Weight
25006.40 Da
Polymer
1
Molecule
Immunoglobulin alpha Fc receptor
Chain Length
218 amino acids
Crystal Description
PDB ID
1UCT
MMDB ID
24338
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.1 Å
Gene Information
Gene Name
FCAR
Synonyms
XXbac-BPG230H20.5, CD89; Fc alpha receptor; IgA Fc receptor; OTTHUMP00000068692; OTTHUMP00000068696; OTTHUMP00000068697; OTTHUMP00000068698; CD89; CD89 antigen; Fc receptor; Fc fragment of IgA, receptor; IgA Fc receptor
UniProt ID
P24071
Gene ID
2204
Chromosome Location
19q13.2-q13.4
Function
IgA binding; receptor activity
Reference
Reference
Ding, Y., Xu, G., Yang, M., Yao, M., Gao, G.F., Zhang, W., Rao, Z. Crystal Structure of the Ectodomain of Human Fc{alpha}RI.J.Biol.Chem. 2003; 278: 27966-27970