Creative Biostructure

Online Inquiry

Please enter "biostructure" as the verification code.

GMPR2 Protein Crystal

(CBCRY17)  Download Datasheet
Background
Background
Guanosine monophosphate reductase (GMPR) Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation.
Molecular Description
Protein Classification
Oxidoreductase
Structure Weight
161477.73 Da
Polymer
1
Molecule
GMP reductase 2
Chain Length
366 amino acids
Crystal Description
PDB ID
2A7R
MMDB ID
37032
Source
E.coli
Method
X-Ray Diffraction
Resolution
3.0 Å
Ligand Chemical Component
guanosine-5'-monophosphate; sulfate ion
Gene Information
Gene Name
GMPR2
Synonyms
MGC15084; MGC830; GMP reductase 2; guanosine 5'-monophosphate oxidoreductase 2; guanosine monophosphate reductase isolog; EC 1.7.1.7
UniProt ID
Q9P2T1
Gene ID
51292
Chromosome Location
14q12
Function
GMP reductase activity; metal ion binding; oxidoreductase activity; potassium ion binding
Reference
Reference
Li, J., Wei, Z., Zheng, M., Gu, X., Deng, Y., Qiu, R., Chen, F., Ji, C., Gong, W., Xie, Y., Mao, Y. (2006) Crystal Structure of Human Guanosine Monophosphate Reductase 2 (GMPR2) in Complex with GMP J.Mol.Biol. 355: 980-988