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IDI1 Protein Crystal

(CBCRY10)  Download Datasheet
Background
Background
IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity.
Molecular Description
Protein Classification
Isomerase
Structure Weight
56107.39 Da
Polymer
1
Molecule
Isopentenyl-diphosphate delta-isomerase 1
Chain Length
255 amino acids
Crystal Description
PDB ID
2I6K
MMDB ID
46256
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.00 Å
Ligand Chemical Component
Acetic acid; Aminoethanolpyrophosphate; Magnesium ion; Manganese ion
Gene Information
Gene Name
IDI1
Synonyms
IPP1; IPPI1; EC 5.5.5.2; IPP isomerase; IPP isomerase; OTTHUMP00000018951; isopentenyl diphosphate dimethylallyl diphosphate isomerase 1; isopentenyl pyrophosphate isomerase 1; isopentenyl-diphosphate delta isomerase
UniProt ID
Q13907
Gene ID
3422
Chromosome Location
10p15.3
Function
magnesium ion binding; isopentenyl-diphosphate delta-isomerase activity; hydrolase activity; isomerase activity; metal ion binding
Reference
Reference
Zhang, C., Liu, L., Xu, H., Wei, Z., Wang, Y., Lin, Y., Gong, W. (2007) Crystal structures of human IPP isomerase: new insights into the catalytic mechanism J.Mol.Biol. 366: 1437-1446