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IL2 with IL2RA Protein Crystal

(CBCRY33)  Download Datasheet
Background
Background
Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits.
Molecular Description
Protein Classification
Immune System
Structure Weight
40207.9 Da
Polymer
1
Molecule
Interleukin-2
Chain Length
133 amino acids
Polymer
2
Molecule
Interleukin-2 receptor alpha chain
Chain Length
219 amino acids
Crystal Description
PDB ID
1Z92
MMDB ID
33820
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.80 Å
Gene Information
Gene Name
IL2
Synonyms
IL-2; TCGF; lymphokine; T cell growth factor; aldesleukin; interleukin-2; involved in regulation of T-cell clonal expansion; Aldesleukin
UniProt ID
P60568
Gene ID
3558
Chromosome Location
4q26-q27
Function
cytokine activity; interleukin-2 receptor binding; protein binding; growth factor activity; kinase activator activity
Gene Name
IL2RA
Synonyms
RP11-536K7.1; CD25; IDDM10; IL2R; TCGFR; Interleukin-2 receptor; OTTHUMP00000019030; OTTHUMP00000044870; interleukin 2 receptor, alpha chain; IL-2-RA; IL2-RA; CD25 antigen; IL2 receptor alpha subunit; TAC antigen; interleukin 2 receptor, alpha
UniProt ID
P60568
Gene ID
3558
Chromosome Location
10p15-p14
Function
cytokine activity; interleukin-2 receptor binding; protein binding; growth factor activity; kinase activator activity
Reference
Reference
Rickert, M., Wang, X., Boulanger, M.J., Goriatcheva, N., Garcia, K.C. (2005) The structure of interleukin-2 complexed with its alpha receptor. Science 308: 1477-1480