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MAD2 Protein Crystal

(CBCRY02)  Download Datasheet
Background
Background
MAD2 (mitotic arrest deficient 2) is one of the kinetochore protein present on the chromosome during cell division. It is involved in making sure all chromosomes are attached to the mitotic spindle before the beginning of anaphase.
Molecular Description
Protein Classification
Cell Cycle
Structure Weight
288687.00 Da
Polymer
1
Molecule
Mitotic Spindle assembly checkpoint protein MAD2A
Chain Length
206 amino acids
Crystal Description
PDB ID
2VFX
MMDB ID
63130
Source
E.coli
Method
X-Ray Diffraction
Resolution
1.95 Å
Ligand Chemical Component
Chloride ion, Magnesium ion, PE3, PE4, PEG
Gene Information
Gene Name
MAD2L1
Synonyms
HSMAD2; MAD2; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like 1; MAD2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1
UniProt ID
Q13257
Gene ID
4085
Chromosome Location
4q27
Function
protein binding
Reference
Reference
Yang, M., Li, B., Liu, C.-J., Tomchick, D.R., Machius, M., Rizo, J., Yu, H., Luo, X. (2008) Insights Into MAD2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric MAD2 Dimer. Plos Biol. 6: E50