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MARK3 Protein Crystal

(CBCRY42)  Download Datasheet
Background
Background
The protein encoded by MARK3 is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Microtubule affinity-regulating kinase 3 phosphorylates CDC25C on 'Ser-216'. It regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.
Molecular Description
Protein Classification
Transferase
Structure Weight
75337.80 Da
Polymer
1
Molecule
MAP/microtubule affinity-regulating kinase 3
Chain Length
328 amino acids
Crystal Description
PDB ID
2QNJ
MMDB ID
59510
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.70 Å
Gene Information
Gene Name
MARK3
Synonyms
CTAK1, EMK2
UniProt ID
P27448
Gene ID
4140
Chromosome Location
14q32.32
Function
ATP binding; protein serine/threonine kinase activity
Reference
Reference
Murphy, J.M., Korzhnev, D.M., Ceccarelli, D.F., Briant, D.J., Zarrine-Afsar, A., Sicheri, F., Kay, L.E., Pawson, T. Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain. (2007) Proc.Natl.Acad.Sci.Usa 104: 14336-14341