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PABPN1 Protein Crystal

(CBCRY37)  Download Datasheet
Background
Background
Poly(A) binding protein, nuclear 1, also known as PABPN1, is required for progressive and efficient polymerization of poly(A) tails on the 3' ends of eukaryotic genes and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm.
Molecular Description
Protein Classification
RNA binding protein
Structure Weight
43445.20 Da
Polymer
1
Molecule
Polyadenylate-binding protein 2
Chain Length
96 amino acids
Crystal Description
PDB ID
3B4M
MMDB ID
61872
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.82Å
Gene Information
Gene Name
PABPN1
Synonyms
OPMD; PAB2; PABP2; poly(A) binding protein 2; poly(A) binding protein II; poly(A) binding protein, nuclear 1
UniProt ID
Q86U42
Gene ID
8106
Chromosome Location
14q11.2-q13
Function
nucleotide binding; nucleic acid binding; RNA binding; protein binding
Reference
Reference
Ge, H., Zhou, D., Tong, S., Gao, Y., Teng, M., Niu, L. (2008) Crystal structure and possible dimerization of the single RRM of human PABPN1 Proteins 71: 1539-1545