Creative Biostructure

Online Inquiry

Please enter "biostructure" as the verification code.

PAK1 Protein Crystal

(CBCRY51)  Download Datasheet
Background
Background
p21 protein (Cdc42/Rac)-activated kinase 1 belongs to the family of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. Protein kinase regulates cell motility and morphology, and plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes.
Molecular Description
Protein Classification
Transferase
Structure Weight
88460.94 Da
Polymer
1
Molecule
SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA AUTOREGULATORY DOMAIN
Chain Length
80 amino acids
Polymer
2
Molecule
SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA KINASE DOMAIN
Chain Length
297 amino acids
Crystal Description
PDB ID
1F3M
MMDB ID
13568
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.30 Å
Ligand Chemical Component
IODIDE ION
Gene Information
Gene Name
PAK1
Synonyms
PAKalpha; Alpha-PAK; p21-activated kinase 1; p65-PAK
UniProt ID
Q13153
Gene ID
5058
Chromosome Location
11q13-q14
Function
ATP binding;collagen binding; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding
Gene Name
PAK1
Synonyms
PAKalpha; Alpha-PAK; p21-activated kinase 1; p65-PAK
UniProt ID
Q13153
Gene ID
5058
Chromosome Location
11q13-q14
Function
ATP binding;collagen binding; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding
Reference
Reference
Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ, Harrison SC. Structure of pak1 in an autoinhibited conformation reveals a multistage activation switch. Cell(Cambridge,Mass.) (2000) 102 p.387