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PDE2A Protein Crystal(CBCRY48)

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Product Summary
Name PDE2A Protein Crystal
Download Datasheet
Cat No.CBCRY48
FragmentResidues 215-900
Protein DescriptionPhosphodiesterase 2
BackgroundThe phosphodiesterases (PDEs) are a superfamily of enzymes that metabolically inactivate cAMP and cGMP to play key roles in both these aspects of regulation. There are 11 PDE gene families, which differ broadly in specificity and affinity for cAMP and cGMP. An isoform PDE2A2 is supposed to regulates mitochondrial cAMP levels and respiration.
Protein ClassificationHydrolase
Structure Weight158085.17 Da
MethodX-Ray Diffraction
Resolution3.02 Å
Ligand Chemical ComponentMg2+ Zn2+
ReferencePandit J, Forman MD, Fennell KF, Dillman KS, Menniti FS. Mechanism for the allosteric regulation of phosphodiesterase 2a deduced from the x-ray structure of a near full-length construct. Proc.Natl.Acad.Sci.Usa (2009) 106 p.18225

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