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PI3Kα Protein Crystal

(CBCRY44)  Download Datasheet
Background
Background
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
Molecular Description
Protein Classification
Transferase/oncoprotein
Structure Weight
161490.30 Da
Polymer
1
Molecule
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Chain Length
1096 amino acids
Polymer
2
Molecule
Phosphatidylinositol 3-kinase regulatory subunit alpha
Chain Length
279 amino acids
Crystal Description
PDB ID
2RD0
MMDB ID
61532
Source
Spodoptera frugiperda
Method
X-Ray Diffraction
Resolution
3.05 Å
Gene Information
Gene Name
PIK3CA
Synonyms
MCM; CWS5; MCAP; PI3K; CLOVE; MCMTC; p110-alpha
UniProt ID
P27986
Gene ID
5290
Chromosome Location
3q26.3
Function
1-phosphatidylinositol-3-kinase regulator activity; ErbB-3 class receptor binding; insulin binding; insulin-like growth factor receptor binding; insulin receptor binding; insulin receptor substrate binding; neurotrophin TRKA receptor binding; phosphatidylinositol 3-kinase binding; phosphatidylinositol 3-kinase regulator activity
Gene Name
PIK3CA
Synonyms
MCM; CWS5; MCAP; PI3K; CLOVE; MCMTC; p110-alpha
UniProt ID
P27986
Gene ID
5290
Chromosome Location
3q26.3
Function
1-phosphatidylinositol-3-kinase regulator activity; ErbB-3 class receptor binding; insulin binding; insulin-like growth factor receptor binding; insulin receptor binding; insulin receptor substrate binding; neurotrophin TRKA receptor binding; phosphatidylinositol 3-kinase binding; phosphatidylinositol 3-kinase regulator activity
Reference
Reference
Huang CH, Mandelker D, Schmidt-Kittler O, Samuels Y, Velculescu VE, Kinzler KW, Vogelstein B, Gabelli SB, Amzel LM. The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic pi3kalpha mutations. Science (2007) 318 p.1744