Creative Biostructure

Online Inquiry

Please enter "biostructure" as the verification code.

PLK2 Protein Crystal

(CBCRY54)  Download Datasheet
Background
Background
Polo-like kinase 2 (PLK2) is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Polo-like kinases are the key regulators of cell cycle progression, the members of which share a kinase domain and a polo-box domain that serves as a protein-binding module.
Molecular Description
Protein Classification
Transferase
Structure Weight
50489.28 Da
Polymer
1
Molecule
Serine/threonine-protein kinase PLK2
Chain Length
218 amino acids
Crystal Description
PDB ID
4XB0
MMDB ID
129103
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.70 Å
Ligand Chemical Component
PO4-,Cl-
Gene Information
Gene Name
PLK2
Synonyms
SNK; hSNK; hPlk2
UniProt ID
Q9NYY3
Gene ID
10769
Chromosome Location
5q12.1-q13.2
Function
ATP binding; protein serine/threonine kinase activity; signal transducer activity
Reference
Reference
Kim JH, Ku B, Lee KS, Kim SJ. Structural analysis of the polo-box domain of human polo-like kinase 2. Proteins (2015)