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PLK4 Protein Crystal

(CBCRY56)  Download Datasheet
Background
Background
Polo-like kinase 4 (PLK4) belongs to the polo family of serine/threonine protein kinases. PLK4 localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. PLK4 is involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1.
Molecular Description
Protein Classification
Transferase
Structure Weight
64844.43 Da
Polymer
1
Molecule
Serine/threonine-protein kinase PLK4
Chain Length
278 amino acids
Crystal Description
PDB ID
3COK
MMDB ID
63866
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.25 Å
Ligand Chemical Component
SULFATE ION, ANP
Gene Information
Gene Name
PLK4
Synonyms
SAK; STK18; MCCRP2
UniProt ID
O00444
Gene ID
10733
Chromosome Location
4q28
Function
ATP binding; protein serine/threonine kinase activity
Reference
Reference
Atwell S, Burley SK, Houle A, Leon B, Pelletier LA, Sauder JM. Crystal structure of plk4 kinase. No recorded citation in PubMed.