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PTP1B Protein Crystal

(CBCRY52)  Download Datasheet
Background
Background
Tyrosine-protein phosphatase non-receptor type 1 belongs to tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. Tyrosine-protein phosphatase acts as a regulator of endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK, and also regulates the hepatocyte growth factor receptor signaling pathway.
Molecular Description
Protein Classification
Hydrolase
Structure Weight
37896.55 Da
Polymer
1
Molecule
PROTEIN TYROSINE PHOSPHATASE 1B
Chain Length
321 amino acids
Crystal Description
PDB ID
1PTY
MMDB ID
57182
Source
E.coli
Method
X-Ray Diffraction
Resolution
1.85 Å
Ligand Chemical Component
Mg2+, O-PHOSPHOTYROSINE
Gene Information
Gene Name
PTPN1
Synonyms
PTP1B
UniProt ID
P18031
Gene ID
5770
Chromosome Location
20q13.1-q13.2
Function
enzyme binding; ephrin receptor binding; poly(A) RNA binding; protein kinase binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; zinc ion binding
Reference
Reference
Puius YA, Zhao Y, Sullivan M, Lawrence DS, Almo SC, Zhang ZY. Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed With Two Phosphotyrosine Molecules.