Creative Biostructure

Online Inquiry

Please enter "biostructure" as the verification code.

PYCR1 Protein Crystal

(CBCRY27)  Download Datasheet
Background
Background
Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor. The enzymatic cycle between P5C and proline is very important for the regulation of amino acid metabolism, intracellular redox potential, and apoptosis.
Molecular Description
Protein Classification
Oxidoreductase
Structure Weight
168155.50 Da
Polymer
1
Molecule
Pyrroline-5-carboxylate reductase 1
Chain Length
321 amino acids
Crystal Description
PDB ID
2GER
MMDB ID
41542
Source
E.coli
Method
X-Ray Diffraction
Resolution
3.1Å
Gene Information
Gene Name
PYCR1
Synonyms
P5C; P5CR; PIG45; PP222; PYCR; P5C reductase; proliferation-inducing protein 45; pyrroline-5-carboxylate reductase 1; EC 1.5.1.2; P5C reductase 1; P5CR1
UniProt ID
P32322
Gene ID
5831
Chromosome Location
17q25.3
Function
binding; oxidoreductase activity; pyrroline-5-carboxylate resuctase activity
Reference
Reference
Meng, Z., Lou, Z., Liu, Z., Li, M., Zhao, X., Bartlam, M., Rao, Z. (2006) Crystal structure of human pyrroline-5-carboxylate reductase J.Mol.Biol. 359: 1364-1377