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PYCR2 Protein Crystal

(CBCRY25)  Download Datasheet
Background
Background
Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor. The enzymatic cycle between P5C and proline is very important for the regulation of amino acid metabolism, intracellular redox potential, and apoptosis
Molecular Description
Protein Classification
Oxidoreductase
Structure Weight
149791.08 Da
Polymer
1
Molecule
Pyrroline-5-carboxylate reductase 2
Chain Length
277 amino acids
Crystal Description
PDB ID
2GR9
MMDB ID
41570
Source
E.coli
Method
X-Ray Diffraction
Resolution
3.1Å
Ligand Chemical Component
Magnesium ion; Sulfate ion
Gene Information
Gene Name
PYCR2
Synonyms
P5CR2; OTTHUMP00000035614; pyrroline 5-carboxylate reductase isoform; EC 1.5.1.2; P5C reductase 2; pyrroline-5-carboxylate reductase family, member 2; FLJ54750; RP4-559A3.4
UniProt ID
Q96C36
Gene ID
29920
Chromosome Location
1q42.12
Function
catalytic activity; binding; pyrroline-5-carboxylate reductase activity; Oxidoreductase activity
Reference
Reference
Meng, Z., Lou, Z., Liu, Z., Li, M., Zhao, X., Bartlam, M., Rao, Z. (2006) Crystal structure of human pyrroline-5-carboxylate reductase J.Mol.Biol. 359: 1364-1377