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SAT1 Protein Crystal

(CBCRY21)  Download Datasheet
Background
Background
Spermidine/spermine N(1)-acetyltransferase (SSAT; EC 2.3.1.57) is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the N(1)-acetylation of spermidine and spermine and, by the successive activity of polyamine oxidase, spermine can be converted to spermidine and spermidine to putrescine.
Molecular Description
Protein Classification
Transferase
Structure Weight
42238.60 Da
Polymer
1
Molecule
Diamine acetyltransferase 1
Chain Length
179 amino acids
Crystal Description
PDB ID
2G3T
MMDB ID
38382
Source
E.coli
Method
X-Ray Diffraction
Resolution
1.8Å
Gene Information
Gene Name
SAT1
Synonyms
DC21; EC 2.3.1.57; KFSD; SAT; SSAT; SSAT-1;OTTHUMP00000023061; diamine N-acetyltransferase 1; diamine acetyltransferase 1; spermidine/spermine N1-acetyltransferase alpha; spermidine/spermine N1-acetyltransferase 1; Polyamine N-acetyltransferase 1; Putrescine acetyltransferase
UniProt ID
P21673
Gene ID
6303
Chromosome Location
Xp22.1
Function
acyltransferase activity; diamine N-acetyltransferase activity; transferase activity
Reference
Reference
Zhu, Y.Q., Zhu, D.Y., Yin, L., Zhang, Y., Vonrhein, C., Wang, D.C. (2006) Crystal structure of human spermidine/spermine N1-acetyltransferase (hSSAT): the first structure of a new sequence family of transferase homologous superfamily Proteins 63: 1127-1131