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SET7/9 Protein Crystal

(CBCRY57)  Download Datasheet
Background
Background
Histone-lysine N-methyltransferase SETD7 belongs to histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. It can be recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. SETD7 has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Molecular Description
Protein Classification
Transferase
Structure Weight
33421.14 Da
Polymer
1
Molecule
SET domain-containing protein 7
Chain Length
297 amino acids
Crystal Description
PDB ID
1N6C
MMDB ID
21841
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.30 Å
Ligand Chemical Component
S-ADENOSYLMETHIONINE
Gene Information
Gene Name
SETD7
Synonyms
KMT7; SET7; SET9; SET7/9
UniProt ID
Q8WTS6
Gene ID
80854
Chromosome Location
4q28
Function
chromatin binding; histone-lysine N-methyltransferase activity; p53 binding; protein-lysine N-methyltransferase activity
Reference
Reference
Kwon T, Chang JH, Kwak E, Lee CW, Joachimiak A, Kim YC, Lee J, Cho Y. Mechanism of histone lysine methyl transfer revealed by the structure of set7/9-adomet. Embo J. (2003) 22 p.292