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VPS29 Protein Crystal

(CBCRY38)  Download Datasheet
Background
Background
VPS29 belongs to a group of genes coding for vacuolar protein sorting (VPS) proteins that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene, Vps29, is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. Vps29 may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment.
Molecular Description
Protein Classification
cytoplasmic protein
Structure Weight
20531.90 Da
Polymer
1
Molecule
Vacuolar Protein Sorting Protein 29
Chain Length
182 amino acids
Crystal Description
PDB ID
1W24
MMDB ID
32322
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.10Å
Gene Information
Gene Name
VPS29
Synonyms
DC15; DC7; DKFZp564F0223; FLJ20492; PEP11; retromer protein; vacuolar protein sorting 29; vacuolar sorting protein VPS29/PEP11; x 007 protein; EC 3.1.3.3; hVPS29; vesicle protein sorting 29
UniProt ID
Q9UBQ0
Gene ID
51699
Chromosome Location
12q24
Function
zinc ion binding; hydrolase activity; metal ion binding
Reference
Reference
Wang, D., Guo, M., Liang, Z., Fan, J., Zhu, Z., Zang, J., Zhu, Z., Li, X., Teng, M., Niu, L., Dong, Y., Liu, P. (2005) Crystal Structure of Human Vacuolar Protein Sorting Protein 29 Reveals a Phosphodiesterase/Nuclease-Like Fold and Two Protein-Protein Interaction Sites. J.Biol.Chem. 280: 22962