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In vivo Magnetic Resonance Imaging

Magnetic Resonance Spectroscopy (MRS) is a non-invasive, radiation-free analytical technique that has been used to study brain tumors and many other diseases. One associated technique is magnetic resonance imaging (MRI). MRI employs NMR signal of protons to create 2-dimensional images of tissues, and its use for studying cardiovascular disease processes in small animals has increased tremendously recently. With the state-of-the-art MRI instruments, Creative Biostructure provides small animal imaging solution for research projects involving in vivo measurements of structure or function of tissues.

Small animal MRI has become invaluable tools in preclinical and pharmaceutical research for organ, tissue, and cell observation. It provides high-resolution images that can be used to investigate rodent biology, disease models, and discovery of drugs. The most common MRI sequences are T1-weighted (longitudinal relaxation time) and T2-weighted (transverse relaxation time) scans, and they can be used to characterize tissues such as brain and heart; Diffusion-weighted resonance (DWI) use the diffusion of water molecules to generate contrast in MR images, enable the mapping of the diffusion process of molecules in biological tissues in vivo; A special kind of DWI, diffusion tensor imaging (DTI) can be used to map whit matter tractography in the brain; Blood-oxygen-level dependent imaging (BOLD) is employed to observe different areas of the brain or other organs; Functional MRI (fMRI) use BOLD contrast imaging to determine which parts of the brain are most active. Below is a list of MRI imaging services offered by Creative Biostructure.

In vivo Magnetic Resonance Spectroscopy

Imaging services

  • T1 and T2 weighted images
  • Proton density
  • Diffusion-weighted imaging (DWI)
  • Diffusion tensor imaging (DTI)
  • Functional MRI
  • BOLD
  • MRS
  • MR fingerprints

Supported by dozens of scientists with extensive experience in rodent MR imaging, Creative Biostructure dedicates to help clients with consulting on design of customized imaging procedures, data collection and interpretation, as well as report generation. Please feel free to consult with us through online inquiry.

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  1. Desai M., Kahn I., Knoblich U, Bernstein J., Atallah H., Yang A., Kopell N., Bukner R., Boyden E. (2011) Mapping brain networks in awake mice using combined optical neural control and fMRI. J Neurophysiol. 105: 1393-1405.
  2. Beckmann N., Kneuer R, Gremlich H., Karmouty-Quintana H., and Matthias M. (2007) In vivo mouse imaging and spectroscopy in drug discovery. NMR in Biomedicine 20: 154-185.
  3. Bakermans A., Abdurrachim D., Moonen R, Motaal A., Prompers J, Strijkers G., Vandoorne K., and Nicolay K. (2015) Small animal cardiovascular MR imaging and spectroscopy. Progress in Nuclear Magnetic Resonance Spectroscopy. 88-89: 1-47.

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