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Mempro™ Liposome in Cosmetics

Creative Biostructure has established a novel and comprehensive Mempro™ Liposome platform in the past years. Since the first discovery of liposomes, liposome-derived technologies have become one of the most important parts in nanotechnology. Liposomes are small vesicles which are created by suspension of amphiphilic lipids in an aqueous environment, enclosing an aqueous core. A variety of functional components can be incorporated into liposomes within their interior, providign them versatility. Depending on their inherent lipophilicity or hydrophilicity, materials can be entrapped either in the aqueous phase or in the lipid bilayer. Liposomes can be made of naturally occurring substances entirely, therefore, they are nontoxic, biodegradable and non immunogenic. Due to liposome versatility and ability to perform as targeted carrier systems for both water and oil-soluble compounds with controlled release, they have been used in a variety of industrial applications including cosmetics.

Figure 1. Structure of nano-structures widely used in nanotechnology. (Z. Fakhravar1, et al.  2016) Figure 1. Structure of nano-structures widely used in nanotechnology. (Z. Fakhravar1, et al. 2016)

It has attracted attentions of researchers for many years since lipid vesicles can be used as systemic and topical drug delivery systems. Liposomes protect contents encapsulated in them from the outside environment, while allowing small molecules to pass inside/outside to the membranes. Liposomes mimic the living cells, and have been used as membrane models to study the structure and function of membrane proteins. They are biologically compatible with the human skin and body, and they have been used in a wide variety of pharmaceutical and cosmetic systems. The liposome bilayer structure composed of phospholipids or sphingolipids which resembles natural membranes, making Mempro™ Liposome Technology such a powerful tool in cosmetic industry.

Depending on their composition, liposomes can mediate the fluidity of cell membrane and fuse with cells in order to deliver active drugs and components to the target site. Liposomes do not penetrate or permeate the skin as intact vesicles, but transform into small fragments. Liposomes provide a lot of advantages since the lipids components are well hydrated and able to reduce the dryness of the skin, which is the primary cause for its ageing. The vesicles added in creams, ointments, and other solutions will deliver active drugs in a concentration dependent pattern through the stratum corneum to the dermis and epidermis. Liposome cosmetics range from pastes (creams, gels, and ointments) to formulations containing a variety of extracts, moisturizers, antibiotics, and functional peptides/proteins for wound or sunburn healing. Because of their high and long lasting moisture content, most liposomal products are used in anti-ageing creams. Other liposomal products include sunscreens, perfumes, hair conditioners, and aftershaves. We should note that simple liposome formations do not allow penetration into the lower epidermal layers of the skin, therefore, liposomal products are of minor value as transdermal drug delivery systems.

Besides cosmetics, Mempro™ Liposome Technology has also been applied in a broad range of fields such as food industry, drug delivery, cancer therapy, gene therapy, and encapsulation, etc. Creative Biostructure is able to offer you the first-class products services. Please feel free to contact us for a detailed quote.

References:
Z. Fakhravar1, et al. (2016). Nanoliposomes: Synthesis methods and applications in cosmetics. Journal of Cosmetic and Laser Therapy, 18(3): 174–181.
D. A. Balazs and W. T. Godbey. (2012). Liposme: Methods of preparation and applications. International Journal of Pharmaceutical Studies and Research, III(II): 14-20.
F. Guo, et al. (2015). Preparation of PEG-modified proanthocyanidin liposome and its application in cosmetics. Eur Food Res Technol., 240:1013–1021.


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