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Particle Identification, Characterization and Tabulation

Since electron microscope (EM) readily reveals the structures of biological and inorganic molecules at higher resolution than light microscope, it has been used preferably to investigate the ultrastructure including organisms, tissues, cells, macromolecules, and metals providing detailed structural information about the analytes.

Transmission electron microscope (TEM) is the original form of EM, and has played an important role in the early discovery of viruses, such as Ebola virus, hepatitis A virus, hepatitis B virus, SARSCov. In early years, TEM, as one of methods for rapid virus detection, has been used extensively in identifying pathogens of unknown origins. But the emerging of cryo-EM has largely replaced TEM in virus detection, and is now considered as the mainstream technology for studying the structure of biological macromolecules at near-atomic resolution. EM is not only used in virus identification and characterization, but also in identifying biological particles (Figure 1) and inorganic molecules (Figure 2). Creative Biostructure has a wealth of experience in studying EM technology, and is dedicated to provide our customer with a great insight into sciences.

Image analysis of A. aeolicus complex I particles. (A) Self-organizing map from a neural network analysis of 1500 aligned particles. The numbers in the label of each square indicate the number of images that contribute to this node in the map. (B) and (C) Two averages of A. aeolicus complex I corresponding to a flip (B) and flop (C) position on the carbon support of the EM grid. The averages contain 815 and 685 particles, respectively (scale bar 10 nm). Figure 1. Image analysis of A. aeolicus complex I particles.

SEM and EDS output of PM10 (circle mark in A is showing a burning mark at the monitoring station nearby mine fire and, on the other picture (B), showing small-sized regular deposition of particulate matter) Figure 2. SEM and EDS output of PM10

At Creative Biostructure, we have the cutting-edge EM platform and a group of multidisciplinary specialists to ensure the success of your projects. Our services are guaranteed to keep pace with the evolution of science and technology in order to meet the requirements of our customers.

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  1. Debananda Roy, Gurdeep Singh, Nitin Gosai, Identification of possible sources of atmospheric PM10 using particle size, SEM-EDS and XRD analysis, Jharia Coalfield Dhanbad, India. Environ Monit Assess. 2015; 187: 680.
  2. Guohong Peng, Gunter Fritzsch, et al. Isolation, Characterization and Electron Microscopic Single Particle Analysis of the NADH:Ubiquinone Oxidoreductase (Complex I) from the Hyperthermophilic Eubacterium Aquifex aeolicus. Biochemistry. 2003; 42: 3032-3039.

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