Creative Biostructure provides one-stop MemPro™ gene-to-structure services for membrane protein production, purification, crystallization, structure determination and characterization. Scientists from Creative Biostructure have rich experience and advanced techniques (e.g., energy-dispersive X-ray spectroscopy, NMR spectroscopy and Cyro-Electron Microscopy) to serve customers with membrane protein structure determination and analysis.
Over 50% of modern medical drug targets at membrane proteins, whose structures and functions are largely unknown. However, membrane proteins are known to be difficult to crystallize with traditional methods because of the rich hydrophobic and insoluble features. Creative Biostructure takes advantage of the MemPro™ cell-free system and high-throughput screening detergents for the optimization of high-yield production and purification strategies for membrane proteins in natural conformations.
Creative Biostructure guarantees the following high-standard services:
√ Harvest of purified and functional membrane proteins with proper documentation;
and functional analysis of membrane proteins;
√ Building of structure models for Computer-Aided Drug Design (CADD) and ligand design.
Creative Biostructure can provide custom MemPro™ protein production and analysis services for membrane proteins including but not limited to: