Creative Biostructure

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Name
mCCR5 VLP
Cat No.
CBS-V007
Virus Family
Retrovirus
Composition
Mouse C-C motif chemokine receptor 5, Gag protein
Source
Mammalian recombinant
Protein Conc.
0.6-1.0 mg/mL
Purity
>95% by SDS-PAGE
Presentation
Tris-HCl, pH 7.5
Description
CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation.

We provide highly purified Virus-Like Particles (VLPs) products as antigens, produced in a native format, mostly using a mammalian expression system. Custom VLPs synthesis is also offered presented as a cell lysate or a purified antigen for use in vaccine development (including use as an immunogen) and serological based diagnostic assays. We like to be in touch with our customers so please feel free to contact us for a formal quote.

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