Kinases are a type of enzymes that catalyze the phosphorylation process by chemically transferring phosphate groups from phosphate-donating molecules to specific substrates. Kinases are critical in almost every aspect of cellular functions, including metabolism, cell growth, cell signaling and cellular transport. Depending on the various substrates they act on, kinases are mainly classified into three groups: protein kinases, lipid kinases and carbohydrate kinases. Since deficiency or dysfunction of kinases is always associated with diseases (cancer for example), an increasing number of drugs that inhibit specific kinases are being developed. Here, one of the most useful and effective techniques in discovering inhibitors for kinases is the co-crystallization, which provides a direct evidence for the physical interaction between a kinase and an inhibitor.
Creative Biostructure has extensive experiences in dealing with various projects on kinases, including kinase expression, purification and co-crystallization with small molecules. Thelist of kinases we have been working on is as following:
List of Protein Kinases at Creative Biostructure