MagHelix™ Library Analysis
Creative Biostructure provides multiple analytical services for a molecular or combinatorial library, such as selecting a diverse set of ligands, clustering the library into subgroups, finding outliers, and identifying similar molecules.
MagHelix™ Diverse and Focused Library Design
Creative Biostructure offers a series of tools for selecting compounds with unique properties following a diversity design, and identifying compounds similar to an active compound based on molecular properties and structural fingerprints.
MagHelix™ Combinatorial Library Design
We can generate a virtual library of all potential compounds from the molecular fragments combinatorially.
Our library screening platform can supply customers with high-quality cell-based assays and biochemical analysis to identify new hits and facilitate hit-to-lead
processes. This platform also allows customers to use either in-house assays or choose from hundreds of validated assays for major target classes like kinases, G Protein-Coupled Receptors (GPCRs), P450s, nuclear receptors and ion channels. Creative Biostructure can validate and screen the compound library by established or customized assays based on customers’ needs.
MagHelix™ Library Screening Models
There are more than 200 library screening models such as high-throughput
screening (HTS) and high-content screening (HCS) models in multi-well plates (i.e., 96, 384, 1536). With Creative Biostructure, iterative optimization for lead compounds is made possible. We have partnered with world-leading drug discovery firms, institutes and universities, providing high-quality and cost-effective strategies tailored to their requirements. Some of these lead compounds have been patented and brought into preclinical and clinical phases.
> Nuclear receptors (steroidal and non-steroidal)
> Ion Channels
> Cytochrome P450 enzyme
> Other enzymes: cholinesterases, polymerases, proteases, transferases and phosphodiesterases, including anhydrases, esterases, hydrolases, oxidases, oxygenases, reductases, secretases, synthases, phospholipases and ATPases.
Dimitris K. Agrafiotis, Victor S. Lobanov& F. Raymond Salemme. Combinatorial informatics in the post-genomics era. Nature Reviews Drug Discovery 1, 337-346 (May 2002).
Creative Biostructure supplies the following MagHelix™ In vitro assay services that will benefit your projects:
Library Design and Screening
Hit to Lead
ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) Modeling and Profilling