Creative Biostructure

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MagHelix™ Library Design & Screening

MagHelix™ Library Analysis

Creative Biostructure provides multiple analytical services for a molecular or combinatorial library, such as selecting a diverse set of ligands, clustering the library into subgroups, finding outliers, and identifying similar molecules.

MagHelix™ Diverse and Focused Library Design

Creative Biostructure offers a series of tools for selecting compounds with unique properties following a diversity design, and identifying compounds similar to an active compound based on molecular properties and structural fingerprints.

MagHelix™ Combinatorial Library Design

We can generate a virtual library of all potential compounds from the molecular fragments combinatorially.

MagHelix™ Screening

Our library screening platform can supply customers with high-quality cell-based assays and biochemical analysis to identify new hits and facilitate hit-to-lead processes. This platform also allows customers to use either in-house assays or choose from hundreds of validated assays for major target classes like kinases, G Protein-Coupled Receptors (GPCRs), P450s, nuclear receptors and ion channels. Creative Biostructure can validate and screen the compound library by established or customized assays based on customers’ needs.

MagHelix™ Library Screening Models

There are more than 200 library screening models such as high-throughput screening (HTS) and high-content screening (HCS) models in multi-well plates (i.e., 96, 384, 1536). With Creative Biostructure, iterative optimization for lead compounds is made possible. We have partnered with world-leading drug discovery firms, institutes and universities, providing high-quality and cost-effective strategies tailored to their requirements. Some of these lead compounds have been patented and brought into preclinical and clinical phases.

Major Targets:

> Kinases
> Phosphatases
> Nuclear receptors (steroidal and non-steroidal)
> Ion Channels
> Transporters
> Cytochrome P450 enzyme
> Other enzymes: cholinesterases, polymerases, proteases, transferases and phosphodiesterases, including anhydrases, esterases, hydrolases, oxidases, oxygenases, reductases, secretases, synthases, phospholipases and ATPases.

Library Design & Screening
Dimitris K. Agrafiotis, Victor S. Lobanov& F. Raymond Salemme. Combinatorial informatics in the post-genomics era. Nature Reviews Drug Discovery 1, 337-346 (May 2002).

Creative Biostructure supplies the following MagHelix™ In vitro assay services that will benefit your projects:

Assay Development

  • Assay technologies

Library Design and Screening

  • Targets
  • Targeted diseases
  • Library screening

Hit to Lead

  • Hit evaluation and lead identification
  • Mode of action
  • X-ray Crystallography
  • Customized NMR services

ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) Modeling and Profilling

Natural Products