Structural Biology

1. Protein Domain Prediction
2. ▼Protein Crystallization
   1. Lipidic Cubic Phase Crystallization
   2. Controlled in Meso Phase (CIMP) Crystallization
   3. Co-crystallization
   4. Crystallization of Antibody-Antigen Complexes
   5. Batch Screening for Crystals Production
   6. Peptides Crystallization
   7. Membrane Protein Crystallization
   8. Bicelle Protein Crystallization
   9. Viral Envelope Glycoprotein Crystallization
   10. Electron Crystallography
   11. Trace Fluorescent Labeling Crystallization
   12. Optimization Screening
3. NMR Services
4. ▼Cryo-EM Services
   1. Cryo-EM for Small Proteins
   2. Cryo-EM for Virus-like Particles
   3. Cryo-EM for Membrane Proteins
   4. Cryo-EM for DNA Samples
   5. 4D UEM
   6. Immunoelectron Microscopy Service
5. ▼Data Processing and Interpretation
   1. Crystallography Phase Determination
   2. EM Data Processing and Interpretation
   3. NMR Data Processing and Interpretation
6. Super-Resolution Microscopy Service

Custom Membrane Protein Service

1. Plasmids Construction
2. ▼Membrane Protein Expression
   1. Cell-based Protein Production
   2. Cell-free Protein Synthesis (CFPS)
   3. Liposome Construction
   4. Virus-like Particles (VLPs) Construction
   5. Nanodiscs Construction
   6. Plant-Based Virus-Like Particles Production
   7. Detergent-Free Protein Production
   8. Animal-Free Recombinant Protein Production
   9. Plasma Membrane Isolation
   10. List of Membrane Proteins
3. ▼Protein Purification
   1. Detergent Screening for Membrane Protein Purification
   2. Affinity Chromatography
   3. Ion-Exchange Chromatography
   4. Size-Exclusion Chromatography
   5. Hydrophobic Interaction Chromatography
   6. Reversed Phase Chromatography
   7. TFF/Diafiltration Service
   8. Native Protein Purification
4. Protein Process Development And Manufacturing

Protein Engineering & Analysis

1. ▼Protein Evolution
   1. Library Design and Construction Service
   2. Phylogenetic Tree Construction
2. ▼Mutagenesis Services
   1. Site-Directed Mutagenesis
   2. Site-Saturation Mutagenesis
   3. Randomized Mutagenesis Libraries
   4. Scanning Point Mutation Libraries
   5. Degenerated Mutagenesis Libraries
   6. Truncation Libraries
   7. Combinatorial Assembly Libraries
   8. DNA Shuffling
   9. Codon Optimization Services
3. De Novo Design
4. Rational Design
5. ▼Epitope Mapping Analysis
   1. Epitope Mapping Analysis by 3D-EM
   2. Epitope Mapping Analysis by NMR
   3. Epitope Mapping Analysis by Crystallography
6. ▼Protein Interaction Analysis
   1. Surface Plasmon Resonance (SPR)
   2. Bio-layer Interferometry (BLI)
   3. Isothermal Titration Calorimetry (ITC)
   4. Fluorescence Resonance Energy Transfer (FRET)
   5. Saturation Transfer Differences (STD) NMR
   6. Mircoscale Thermophoresis (MST)
7. ▼Protein Thermodynamics Analysis
   1. Differential Scanning Calorimetry (DSC)
   2. Thermal Gravimetric Analysis (TGA)
   3. Protein Thermal Shift Assay (PTSA)

Drug Discovery

1. Antigen Design and Preparation Service
2. ▼Drug Design
   1. Fragment-Based Drug Discovery (FBDD)
   2. Lead Discovery and Optimization
   3. Virtual Screening
   4. Structure Optimization
   5. Zebrafish Screening
3. In Vitro Assays
4. Drug Conjugation Service

Electron Microscopy Products

1. Scanning Electron Microscopy (SEM) Products
2. Transmission Electron Microscopy (TEM) Products

Virus Like Particles (VLPs)

1. Zika Virus VLP (E, prM/M Proteins)

Protein Crystallography

1. Membrane Protein Crystallization
2. Crystallization Chaperone Strategies
3. Comparison of Cryo-EM, X-Ray and NMR

Citations