From computational prediction to experimental validation, Creative Biostructure supports structure determination, membrane protein production, biophysical assays, exosome/liposome/VLP platforms, and advanced nano-characterization.
Select a core capability to learn how Creative Biostructure connects structural biology, computational modeling, biophysical validation, and bio-nano platform development.
STRUCTURE DETERMINATION
X-ray crystallography, Cryo-EM, NMR, MicroED, and integrative structural biology workflows for proteins, complexes, and challenging biomolecular targets.
FROM PREDICTION TO PROOF
Creative Biostructure connects computational modeling, sample preparation, structure determination, and biophysical validation into one integrated CRO workflow.
Clarify target, sample status, project goal, and technical route.
Use modeling, docking, MD simulation, or SBDD to build hypotheses.
Prepare proteins, complexes, membrane proteins, EVs, liposomes, or VLPs.
Apply X-ray, Cryo-EM, NMR, MicroED, microscopy, or spectroscopy.
Measure binding, kinetics, stability, activity, or delivery performance.
Provide data, reports, structure files, interpretation, and next-step guidance.
Technology Highlights
Explore high-demand structural, biophysical, spectroscopy, microscopy, and interaction analysis technologies to support target validation, mechanism studies, and AI-guided discovery.
Products & Platform Materials
Explore high-quality product platforms supporting structural biology, vesicle engineering, delivery system development, imaging, sample preparation, and downstream industrial applications.
Applications & Industries
Creative Biostructure helps research and industrial teams solve challenges across discovery, diagnostics, delivery, formulation, characterization, and translational development.
Target validation, hit identification, lead optimization, structure-guided design, protein engineering, and mechanism-of-action studies.
Flexible support for proteins, complexes, membrane proteins, particles, materials, and difficult structural or functional questions.
Biomarker discovery, exosome analysis, assay development, protein interaction studies, and analytical characterization.
Exosomes, liposomes, LNPs, VLPs, nanoparticles, microbubbles, cargo loading, and delivery system evaluation.
Encapsulation, vesicle-based formulation, ingredient characterization, stability assessment, and bioactive delivery evaluation.
Composition, morphology, surface chemistry, thermal properties, structure-performance relationships, and failure analysis.
Customer Success & Publications
Explore selected publication-backed projects and customer-authorized case studies showing how Creative Biostructure supports structural biology, Cryo-EM, exosome analysis, particle morphology, and antibody complex characterization.
Creative Biostructure provided X-ray crystallographic support for a PNAS-published study investigating tetflupyrolimet and plant DHODH binding.
Problem: Confirming the binding mode of a novel herbicidal scaffold.
Solution: DHODH–tetflupyrolimet X-ray crystallographic support.
Outcome: Structural evidence supported target-site validation and herbicidal mechanism discovery.
Evidence: Kang, I.-H. et al., PNAS, 2023.
Cryo-TEM analysis helped verify particle morphology, size distribution, and reproducible nanodisc formation from bacterial total lipid extracts.
Problem: Confirming nanoscale morphology and homogeneity of bacterial lipid nanodiscs.
Solution: Cryo-TEM particle morphology analysis using FEI Talos F200C.
Outcome: Imaging evidence supported reproducible nanodisc formation and size evaluation.
Evidence: Llewellyn, T. R. et al., Chemistry and Physics of Lipids, 2024.
A confidential CDXX receptor and AB-X antibody complex was analyzed using SEC-guided sample assessment, 300 kV Cryo-TEM, SPA, and epitope analysis.
Problem: Resolving receptor-antibody architecture and epitope-level interaction details.
Solution: Negative staining TEM, 300 kV Cryo-TEM, SPA reconstruction, model fitting, and epitope analysis.
Outcome: 3.07 Å reconstruction with receptor-antibody interaction and epitope analysis.
Evidence: Customer-authorized confidential case study, Creative Biostructure, 2024.
Creative Biostructure supported a confidential Fab-antigen project from Fab preparation and complex purification to crystallization screening, diffraction, and structure validation.
Problem: Obtaining a high-resolution Fab-antigen complex structure.
Solution: Fab preparation, SEC purification, crystallization screening, optimization, and X-ray structure determination.
Outcome: 1.50 Å structure with well-defined electron density and validated model geometry.
Evidence: Customer-authorized confidential case study, Creative Biostructure, 2024.
Creative Biostructure provided RNA isolation, miRNA sequencing, and bioinformatics analysis for plasma-derived extracellular vesicles in a pediatric-onset MS preprint study.
Problem: Profiling disease- and obesity-associated EV-miRNA signatures from plasma EVs.
Solution: EV RNA isolation, miRNA sequencing, differential expression analysis, and pathway interpretation.
Outcome: EV-miRNA patterns linked to neuroinflammation, immune regulation, lipid metabolism, and obesity-related pathways.
Evidence: Hade, M. D. et al., medRxiv, 2025.
Access useful resources, technical documents, research materials, and direct support channels to move your project forward.
FAQS
Find quick answers about project workflows, service scope, sample requirements, turnaround time, data delivery, and ordering processes.
DOCUMENTS
Download brochures, posters, technical guides, product information, and other materials for internal review or project planning.
KNOWLEDGE HUB
Explore technical articles, application notes, research insights, and educational resources across structural biology and biophysical technologies.
SCIENTIFIC SUPPORT
Talk with our scientific team about your target, sample type, workflow, application goal, or custom CRO project requirements.