Cell: New Research Reveals an Unexpected Mechanism of Action of Antibodies

In a new study, researchers from research institutions such as the University of Washington in the United States studied monoclonal antibodies which were isolated from survivors of the severe acute respiratory syndrome (SARS) or Middle East Respiratory Syndrome (MERS) caused by the coronavirus. These monoclonal antibodies reveal an alarming immune defense strategy against deadly viruses. Atomic and molecular information for these highly potent antibodies may provide new insights into these…

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New Nmr Technology Enables More Sensitive Detection of Biomolecule Structures

Nuclear magnetic resonance spectroscopy is a technique used to study the structure and composition of various molecules, including proteins associated with Alzheimer’s disease and other diseases. Recently, researchers at the Massachusetts Institute of Technology have developed a method to significantly improve the sensitivity of nuclear magnetic resonance spectroscopy (NMR).   Robert Griffin, a professor of chemistry at Arthur Amos Noyes, said that with this new approach, scientists should be able…

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Advanced Imaging Technology Helps Reveal The Internal Features of The Tumor

Recently, researchers at the Lyon Cancer Research Center have demonstrated the potential of imaging technology to study oncology issues. Advanced imaging techniques can differentiate malignant cell populations and monitor the effectiveness of anticancer therapies. The study result is published in the Journal of Physical Review Letters, helping to design new therapeutic molecules and personalization of treatment.   Despite a good understanding of the biology of cancer, 90% of experimental drugs…

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New Study Analyze The High-resolution Three-dimensional Structure of The Virus Coxsackie A10

A research report published in the Journal of Nature Communications reveals the full-particle atomic resolution structure of the three different life cycles of the hand-foot-and-mouth virus Coxsackie A10 (CVA10) and the medium-resolution genomic structure of the capsid intermediate completed by the researcher in the Institute of Biophysics, Chinese Academy of Sciences, which is another important research result after they completed the study of the full-particle structure and function of the…

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Award-Winning Work of the 2018 UC Berkeley Image Competition at the Cell Journal Photo Exhibition

The Molecular Imaging Center (MIC) at the University of California, Berkeley is known for its use of confocal microscopes to produce some of the most compelling images, and has a reputation for being the winner of the MIC Image Contest every year. The winning entries for the 2018 MIC Image Competition will be written in the MIC’s dream calendar and will be presented as part of the Cell Picture Show…

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Nature: Tc Toxin Activation Requires Unfolding and Refolding of a β-Propeller

Bacteria have established strategies for infecting organisms and utilize them as a source of nutrients. Many bacteria use their secreted toxins to simply pierce the outer shell of the cell to destroy the cell membrane. Human pathogens such as Yersinia pestis or other bacteria from Salmonella produce a more subtle mechanism: injecting their toxic substances by using a special toxin complex.   Bacterial toxins are one of the most effective…

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Neuron: Whole-Brain Imaging of Mice during Behavior

In a recent study described in the journal Neuron, the Emily Macé and collaborators of the Botond Roska team demonstrated how functional ultrasound imaging can produce high-resolution full-motion images of the brain for specific behaviors in mice. This non-invasive technique has broad application prospects in ophthalmology, neurological and psychiatric diseases.   “Functional ultrasound imaging produces higher resolution images, and is simpler, cheaper, and easier to use than functional magnetic resonance…

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Cell: New Super-resolution Imaging Technology Developed to Reveal New Phenomena of Organelle Interaction

Li Dong, Ph.D., of the Institute of Biophysics, Chinese Academy of Sciences, and Eric Betzig and Jennifer Lippincott-Schwartz, Ph.D., of the Howard Hughes Medical Research Institute of the United States, published a research paper in Cell entitled “Visualizing intracellular organelle and cytoskeletal interactions at nanoscale resolution on millisecond”. This paper pioneered the grazing incidence structured light illumination super-resolution imaging technology (GI-SIM), which can perform high-speed, long-term, super-resolution imaging of intracellular…

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New Way to Block Cancer Immunosuppression Developed

In a new study, Belgian researchers elucidated the three-dimensional structure of a protein complex that suppresses immune responses on the cell surface. They also discovered how antibodies can block this protein complex and its downstream induced immunosuppression. Such antibodies may be used to activate an immune response against tumor cells in cancer patients, thereby triggering immune cells to destroy the tumor. The results of the study were published online in…

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Recent Advances in Optogenetics (II)

(…Continued)   Cell: optogenetics makes the mouse incarnate the cruel killer doi:10.1016/j.cell.2016.12.027     There is a killer hidden in every mouse. Researchers have found areas of the brain that control predatory behavior and have succeeded in finding a way to control their switches. Dr. Ivan de Araujo from Yale University and colleagues found two nerves in the brain that control the hunting behavior of mice, one coordinated to chase…

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