Cell: New Super-resolution Imaging Technology Developed to Reveal New Phenomena of Organelle Interaction

Li Dong, Ph.D., of the Institute of Biophysics, Chinese Academy of Sciences, and Eric Betzig and Jennifer Lippincott-Schwartz, Ph.D., of the Howard Hughes Medical Research Institute of the United States, published a research paper in Cell entitled “Visualizing intracellular organelle and cytoskeletal interactions at nanoscale resolution on millisecond”. This paper pioneered the grazing incidence structured light illumination super-resolution imaging technology (GI-SIM), which can perform high-speed, long-term, super-resolution imaging of intracellular…

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New Way to Block Cancer Immunosuppression Developed

In a new study, Belgian researchers elucidated the three-dimensional structure of a protein complex that suppresses immune responses on the cell surface. They also discovered how antibodies can block this protein complex and its downstream induced immunosuppression. Such antibodies may be used to activate an immune response against tumor cells in cancer patients, thereby triggering immune cells to destroy the tumor. The results of the study were published online in…

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Recent Advances in Optogenetics (II)

(…Continued)   Cell: optogenetics makes the mouse incarnate the cruel killer doi:10.1016/j.cell.2016.12.027     There is a killer hidden in every mouse. Researchers have found areas of the brain that control predatory behavior and have succeeded in finding a way to control their switches. Dr. Ivan de Araujo from Yale University and colleagues found two nerves in the brain that control the hunting behavior of mice, one coordinated to chase…

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Recent Advances in Optogenetics (I)

Optogenetics is a rapidly developing multi-disciplinary bioengineering technology that integrates optics, software control, gene manipulation technology, and electrophysiology. The main principle is to first use gene manipulation techniques to transfer light-sensitive genes (such as ChR2, eBR, NaHR3.0, Arch or OptoXR, etc.) into specific types of cells in the nervous system for expression of specific ion channels or GPCRs. The photo-sensing ion channel will selectively induce the passage of cations or…

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Cell: New Intelligent Microscope Developed to Observe Post-Implantation Mouse Development

So far, the clearest picture of living embryos comes from zebrafish and fruit flies. Ten years ago, Philipp Keller, a physicist and biologist at the Jenice Research Institute in the Howard Hughes Medical Institute, and his colleagues developed the first “digital embryo” of zebrafish, in which the zebrafish was a transparent striped fish that is usually provided to scientists for research. They scanned the zebrafish embryos with a light sheet…

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Science Advances: The Structure of IgM Revealed

In a new study, researchers from the University of Tokyo in Japan revealed the structure of a vital immune protein called immunoglobulin M (IgM) by using computer image analysis and modern electron microscopy imaging. It offers the possibility of developing more effective drugs for a range of diseases ranging from cancer to nervous system diseases for the future. The results of the study were published on Science Advances, entitled “The…

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Nature: Malaria Parasite Translocon Structure and Mechanism of Effector Export

Malaria is an infectious disease that is transmitted to people through the bite of mosquitoes infected with Plasmodium. It affects more than 200 million people each year and kills nearly half a million people each year. When bitten by a mosquito, the Plasmodium invades human erythrocytes, acquires a portion of the erythrocyte membrane, and forms a protective compartment around it, known as a vacuole.     Normal red blood cells…

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JCB: New Research Reveals the Internal Structure of Macrophages

We live in a world full of risks, many of which are invisible. Fortunately, we did not go this dangerous road alone. There are precious sentinel cells lying in our bodies, and every day they are fighting to keep us alive.   The work of the human immune system is huge and complex. That’s why, despite decades of research, scientists are still working to reveal the full working principle.  …

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Immunity: New Antibody Analysis Method May Accelerate Rational HIV Vaccine Development

In a new study, researchers from the Scripps Research Institute in the United States proposed a faster way to analyze the results of experimental vaccines against HIV and other pathogens. Their new approach allows scientists to quickly assess the full spectrum of antibodies produced by individuals in response to a pathogen or vaccine and determine if these antibodies are likely to be effective against the pathogen. The results of the…

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Nature: Inositol Phosphates Are Assembly Co-factors for HIV-1

In a new study, researchers from Cornell University, the University of Virginia, the University of Delaware, the University of Missouri, the German European Molecular Biology Laboratory, and the Austrian Institute of Science and Technology provided new details of how the HIV-1 viral structure is assembled. This discovery provides a potential new target for the treatment of this viral infection. The relevant research results were published online in Nature.   This…

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