Nature: Tc Toxin Activation Requires Unfolding and Refolding of a β-Propeller

Bacteria have established strategies for infecting organisms and utilize them as a source of nutrients. Many bacteria use their secreted toxins to simply pierce the outer shell of the cell to destroy the cell membrane. Human pathogens such as Yersinia pestis or other bacteria from Salmonella produce a more subtle mechanism: injecting their toxic substances by using a special toxin complex.   Bacterial toxins are one of the most effective…

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