New Research Reveals The Structure of Key Electrical Switches in The Brain

Scientists have revealed the structure of key receptors in the brain that are involved in learning, memory, behavior, and mood. The new study published in the journal of Science reveals the structure of the AMPA receptor in its natural state for the first time. This discovery will bring new ideas to uncover the mechanisms behind a series of neurological disorders and diseases.   “There are some basic electrical switches in…

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Many Studies Show that A Computational Method that Thermally Stabilizes G-protein-coupled Receptors is Promising in The Analysis of Receptor Structures

Researchers from the Moscow Institute of Physical Science and Technology (MIPT), the Skolkovo Institute of Science and Technology (Skoltech) and the University of Southern California (USC) have developed a new computational method to design thermally stable G Protein-coupled receptors (GPCRs), which are very effective in developing new drugs. This method has been shown to be useful for obtaining the structure of several major human receptors. An overview of this new…

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A New Study Analyzed The Structure of The Important Photosynthetic Membrane Protein Super Complex of Pseudomonas Aeruginosa

Recently, a team led by academician of the Chinese Academy of Sciences, researcher of the Institute of Botany, Chinese Academy of Sciences, Tingyun Kuang, and researcher Jianren Shen cooperated with researchers from Jinan University and Tsinghua University revealed an important photosynthetic membrane protein super complex of Pseudomonas aeruginosa – photosystem I light-harvesting complex. I. (PSI-LHCI) 3.49 resolution structure. This study further improved the understanding of the trend of light system…

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Introduction on The Significance of 3D Reconstruction of DNA to Breeding Offspring

From the father to the offspring, the transmission of genetic information requires careful packaging of the DNA in the sperm. However, the way how this DNA is packaged is still unknown. In a recent study, scientists used new techniques to reveal the three-dimensional organization of DNA in mature male germ cells, revealing a critical period of development that helps explain how fathers pass genetic information to offspring.   Research findings…

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A Study Discover New Targets for Targeting Caliciviruses

Norovirus is highly contagious and very difficult to control. In general, the Norovirus epidemic broke out in hospitals, nursing homes, schools, hotels, and cruise ships. Calicivirus, including Norovirus and sapovirus, is also an important animal pathogen, leading to ‘cat flu’ associated with high mortality in domestic cats. In a new study, British researchers used cryo-electron microscopy to study the structure of the feline calicivirus that causes cat flu to better…

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New Developed Methods to Map The Mouse Brain with Unprecedented Precision

The prior technology can make the tissue as clear and transparent as glass and expand it to several times its original size, which provides an unprecedented opportunity for the internal operation of the biopsy system. Recently, Japanese researchers mapped the cellular composition of the mouse brain with unprecedented precision.   System biologist Ueda Taiji and his team at the RIKEN Biosystems Dynamics Research Center in Japan used a technique called…

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Cell: New Research Reveals an Unexpected Mechanism of Action of Antibodies

In a new study, researchers from research institutions such as the University of Washington in the United States studied monoclonal antibodies which were isolated from survivors of the severe acute respiratory syndrome (SARS) or Middle East Respiratory Syndrome (MERS) caused by the coronavirus. These monoclonal antibodies reveal an alarming immune defense strategy against deadly viruses. Atomic and molecular information for these highly potent antibodies may provide new insights into these…

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New Nmr Technology Enables More Sensitive Detection of Biomolecule Structures

Nuclear magnetic resonance spectroscopy is a technique used to study the structure and composition of various molecules, including proteins associated with Alzheimer’s disease and other diseases. Recently, researchers at the Massachusetts Institute of Technology have developed a method to significantly improve the sensitivity of nuclear magnetic resonance spectroscopy (NMR).   Robert Griffin, a professor of chemistry at Arthur Amos Noyes, said that with this new approach, scientists should be able…

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Advanced Imaging Technology Helps Reveal The Internal Features of The Tumor

Recently, researchers at the Lyon Cancer Research Center have demonstrated the potential of imaging technology to study oncology issues. Advanced imaging techniques can differentiate malignant cell populations and monitor the effectiveness of anticancer therapies. The study result is published in the Journal of Physical Review Letters, helping to design new therapeutic molecules and personalization of treatment.   Despite a good understanding of the biology of cancer, 90% of experimental drugs…

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New Study Analyze The High-resolution Three-dimensional Structure of The Virus Coxsackie A10

A research report published in the Journal of Nature Communications reveals the full-particle atomic resolution structure of the three different life cycles of the hand-foot-and-mouth virus Coxsackie A10 (CVA10) and the medium-resolution genomic structure of the capsid intermediate completed by the researcher in the Institute of Biophysics, Chinese Academy of Sciences, which is another important research result after they completed the study of the full-particle structure and function of the…

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