A Novel Protein Based Biosensor for Rapid Detection of Coronavirus Proteins and Antibodies

In a new study, researchers from the University of Washington have developed a new method to detect the proteins that make up the pandemic coronavirus SARS-CoV-2 and antibodies against it. They designed protein-based biosensors that emit light when mixed with the protein components of the virus or specific antibodies to COVID-19. This breakthrough may lead to faster and more extensive detection in the near future. The related research results were…

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Study Revealed the Structural Basis of Assembly Factor Psb27 Regulating the Assembly and Repair of Photosystem II

Photosynthesis is a process of large-scale utilization of solar energy to synthesize carbon dioxide and water into organic compounds and release oxygen. Photosystem Ⅱ (PSⅡ) is located on the thylakoid membrane of oxygen releasing photosynthetic organisms, which is an important place for the oxidation of photosynthetic water. PSⅡ core complex has the function of photosynthesis and oxygen releasing, which is a pigment membrane protein and composed of 20 protein subunits,…

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Determination of the Whole Structure of Protein Complex by Gene Interaction Map

One of the most vexing tasks for biologists is to figure out how proteins, the molecules responsible for the work of cells, do their work. There are knobs, folds, and cracks on the surface of each protein, which determine what it can do. It’s fairly easy for scientists to visualize these features on a single protein. But proteins don’t act alone. Scientists also need to know the shape and composition…

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The High Resolution Structure of NALCN-FAM155a Subchannel Complex Is Reported

In this study, researchers used the single LCNAN particle freezing electron microscopy to explore the mechanism. Since the quaternary complex of NALCN-FAM155-UNC79-UNC80 is not stable enough, they focus on the structural analysis of the relatively stable core subunit of NALCN-FAM155. After homologous protein screening and other steps, they determined the complex composed of rat NALCN and mouse FAM155a subunit as the research object. After overcoming the difficulties of sample preparation…

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Structurally Reveals the Mechanism of Calpain Inhibitor Dual Inhibition of the New Coronavirus Main Protease and Human Cathepsin L

SARS-CoV-2 is a respiratory virus that causes COVID-19 disease. It attacks the human body through multiple steps. Entering cells deep in the lungs and hijacking the molecular machinery of human host cells to produce copies of the virus itself are the first two steps – both of these steps are essential for virus infection.   In a new study, researchers from the University of Arizona and the University of South…

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Scientists Use Live Imaging to Reveal How Hematopoietic Stem Cells Move in the Bone Marrow

Understanding the principle of muscle movement can help us better fitness and weight loss. Understanding the movement principle of stem cells can help us better apply stem cell technologies in clinical practice.   For example, the hematopoietic stem cells of adult mammals reside in the “bone marrow”. This is why the transplantation of hematopoietic stem cells is usually referred to as “bone marrow transplantation”.   In actual bone marrow donation…

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Label-free Single Molecule Optical Imaging Based on Surface Plasmon Resonance Microscope

Single-molecule optical imaging can analyze the morphology and function of a single molecule, so it can not only provide statistical average information of multiple molecules, but also provide single-molecule individual difference information that traditional biosensors cannot provide, allowing us to observe and understand the nature and function of the molecule in the more detail.   The research team of Professor NJ Tao and Professor Shaopeng Wang of the Bioelectronics and…

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The High-resolution Structure of de novo DNA Methyltransferase and Natural Substrate Nucleosomes

Recently, the Xu Huaqiang group of the Shanghai Pharmaceutical Research Institute, Chinese Academy of Sciences, in cooperation with the Peter Jones group and Karsten Melcher group of the US Van Andel Research Institute, used cryo-electron microscopy to analyze the high-resolution structure of the de novo DNA methyltransferase (DNMT3A2/DNMT3B3) and the natural substrate nucleosome. Research describes the binding mode of DNMT3A2/DNMT3B3 and the nucleosome, and proposes a model of genome-wide DNA…

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The Activity of TCP Family Transcription Factors Is Associated with Changes in the 3D Conformation of Chromatin

Genomics research should not stop at obtaining information from genome sequences or epigenetic modifications. An in-depth exploration of three-dimensional chromatin folding is also essential for understanding genome functions. In the past ten years, the advancement of high-throughput sequencing technology and the development of high-resolution imaging technology have made the complex three-dimensional structure of the genome increasingly clearly presented in front of people. Among them, Topologically Associated Domains (TADs) discovered by…

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Near-infrared Zone II Fluorescence Imaging Technology and Its Prospects in Biomedical Applications

Fluorescence imaging technology has broad application prospects in basic biomedical research and clinical diagnostic testing. Near-infrared zone II fluorescence (1000-1700nm, NIR-II) imaging technology overcomes the strong tissue absorption, scattering, and autofluorescence interference faced by traditional fluorescence (400-900nm), and can achieve higher tissue penetration depth in vivo imaging with time and space resolution, it is regarded as the most promising next-generation in vivo fluorescence imaging technology.   Wang Qiangbin, a researcher…

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